Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with postordre brude statistik surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>

Biological targets and you can pharmacology from curcumin

Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin is the significant component of the fresh yellow color away from turmeric, an Indian spruce that is taken from the fresh new rhizome of exotic bush Curcuma longa, which belongs to the Zingiberaceae family relations. Inside section, we talk about the pharmacological affairs out-of curcumin and you may speak about the fresh new molecular basics of these factors. We upcoming feedback the latest proven and you may possible systematic uses out-of curcumin. Curcumin is known over the years since the a therapeutic agent, but the procedure out of action is actually detail by detail. The latest pharmacological results of curcumin seem to be the consequence of an excellent synergism regarding systems off weak biochemical affairs that have multiple physiological needs within the interconnected signaling paths. These purpose were enzymes such as for instance cyclooxygenase, lipoxygenase and you may protein kinases, and you will transcription affairs including NF-?B, STAT and you may Nrf2. Modulation ones particles influences downstream affectors which make the brand new antiinflammatory, antioxidant, chemopreventive, anticancer, and you can antimicrobial products away from curcumin. These effects was in fact checked when you look at the logical samples away from curcumin for aches and you will inflammatory diseases, cancer tumors, Alzheimer state, cardio infection, and all forms of diabetes. The products have used changeable dosages away from curcuminwith various other frequencies and you will stage, into general completion one higher dosages regarding curcumin in the quantity of g are required to obtain therapeutic outcomes. Read more

Curcumin: Synthesis, Growing Part from inside the Serious pain Management and you can Health Implications

Book Chapter Examples of bush-derived pharmaceuticals having end up being the desire off continuous and you will great research and you can creativity notice features, thus far, started slightly scarce. Just after a long period, the final 2 decades was indeed characterized by a great 100-flex boost in what amount of scientific stuff typed per year that was away from significance into the the means to access curcumin inside biomedicine. Find out more

Construction, synthesis and you can physical situations from curcumin prodrugs

Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many possible pharmacological outcomes and may even possess healing programs in several condition claims, just like the chatted about in detail in the last part. Yet not, the possibility scientific efficacy out-of curcumin is restricted of the the physicochemical properties out of terrible drinking water solubility and you may imbalance, which lead to low bioavailability. Prodrugs off curcumin provide a method to improve of one’s biopharmaceutical and you can pharmacokinetic properties, and will enable it to be exploitation of pharmacological results of curcumin. Within part, i earliest opinion the fresh new physicochemical and you can pharmacokinetics regarding curcumin. I after that define the style of curcumin prodrugs with enhanced liquids solubility and you may enhanced chemical balances which can be converted back once again to 100 % free curcumin abreast of bioactivation within the vivo. We high light previous triumph in this area, with a concentrate on the design, synthesis and you may evaluation out-of prodrugs predicated on promoieties and amino acids, fatty acids, nucleic acids, dicarboxylic acids, and you will polymeric materials such as hyaluronic acidic and you may polyethylene glycol. It section comes with the reason behind optimization of your physicochemical and you may biopharmaceutical characteristics additionally the physiological situations out of curcumin prodrugs, towards the goal using of these curcumin types within the health-related apps. Find out more